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KMID : 0665220090220030367
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Korean Journal of Food and Nutrition
2009 Volume.22 No. 3 p.367 ~ p.376
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Antioxidant and Antibacterial Activities of Ethyl Acetate Extract from Scutellaria baicalensis
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Kim Young-Hyun
Paek Jong-Yoon
Kwon Hyun-Jung
Lee Jae-Woo
Yoon Ok-Hyun
Han Man-Deuk
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Abstract
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This study aimed to determine the antioxidant and antibacterial effects of solvent extracts from Scutellaria baicalensis. The S. baicalensis was successively extracted with 5 kinds of solvents. The obtained samples were as follows; hexan fraction (IPK-1), chloroform fraction(IPK-2), ethyl acetate fraction(IPK-3), butanol fraction(IPK-4), and water fraction(IPK-5). These extracts were determined to process antibacterial effects using a paper disc method against 18 species of human pathogenic bacteria, antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl(DPPH) method and inhibiting ability of linoleic acid autoxidation. Extracts of S. baicalensis has shown selective antibacterial effects on various strains of bacteria. Ethyl acetate fraction(IPK-3) showed the highest antimicrobial activity against selective bacteria, such as Staphylococcus aureus 285, S. aureus 503. In antioxidant activity test, free radical scavenger activity of IPK-3 fraction was 92% compared with BHA at the same concentration, while lipid peroxidation inhibition was 48%. These results suggest that IPK-3 fraction of S. baicalensis could be suitable in development of antimicrobial and antioxidant agents.
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KEYWORD
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Scutellaria baicalensis, antioxidant activity, antibacterial activity, ethyl acetate extract
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